Thermodynamics of partitioning of substance P in isotropic bicelles
Identifieur interne : 000119 ( Main/Exploration ); précédent : 000118; suivant : 000120Thermodynamics of partitioning of substance P in isotropic bicelles
Auteurs : Chul Kim [Corée du Sud, États-Unis] ; Seung Bin Baek [Corée du Sud] ; Do Hun Kim [Corée du Sud] ; Sung Chul Lim [Corée du Sud] ; Hyeong Ju Lee [Corée du Sud] ; Hee Cheon Lee [Corée du Sud]Source :
- Journal of Peptide Science [ 1075-2617 ] ; 2009-05.
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Abstract
The temperature dependence of the partition of a neuropeptide, substance P (SP), in isotropic (q = 0.5) bicelles was investigated by using pulsed field gradient NMR diffusion technique. The partition coefficient decreases as the temperature is increased from 295 to 325 K, indicating a favorable (negative) enthalpy change upon partitioning of the peptide. Thermodynamic analysis of the data shows that the partitioning of SP at 300 K is driven by the enthalpic term (ΔH) with the value of − 4.03 kcal mol−1, while it is opposed by the entropic term (−TΔS) by approximately 1.28 kcal mol−1 with a small negative change in heat capacity (ΔCp). The enthalpy‐driven process for the partition of SP in bicelles is the same as in dodecylphosphocholine (DPC) micelles, however, the negative entropy change in bicelles of flat bilayer surface is in sharp contrast with the positive entropy change in DPC micelles of highly curved surface, indicating that the curvature of the membrane surface might play a significant role in the partitioning of peptides. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
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DOI: 10.1002/psc.1121
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Peptide Sci.</title><idno type="ISSN">1075-2617</idno><idno type="eISSN">1099-1387</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2009-05">2009-05</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="353">353</biblScope><biblScope unit="page" to="358">358</biblScope></imprint><idno type="ISSN">1075-2617</idno></series><idno type="istex">A767C9F68EBF313DAB735D170CB8D590C5D71394</idno><idno type="DOI">10.1002/psc.1121</idno><idno type="ArticleID">PSC1121</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1075-2617</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PFG NMR</term><term>diffusion coefficient</term><term>isotropic bicelle</term><term>partition coefficient</term><term>partitioning</term><term>substance P</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The temperature dependence of the partition of a neuropeptide, substance P (SP), in isotropic (q = 0.5) bicelles was investigated by using pulsed field gradient NMR diffusion technique. The partition coefficient decreases as the temperature is increased from 295 to 325 K, indicating a favorable (negative) enthalpy change upon partitioning of the peptide. Thermodynamic analysis of the data shows that the partitioning of SP at 300 K is driven by the enthalpic term (ΔH) with the value of − 4.03 kcal mol−1, while it is opposed by the entropic term (−TΔS) by approximately 1.28 kcal mol−1 with a small negative change in heat capacity (ΔCp). The enthalpy‐driven process for the partition of SP in bicelles is the same as in dodecylphosphocholine (DPC) micelles, however, the negative entropy change in bicelles of flat bilayer surface is in sharp contrast with the positive entropy change in DPC micelles of highly curved surface, indicating that the curvature of the membrane surface might play a significant role in the partitioning of peptides. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Chul" sort="Kim, Chul" uniqKey="Kim C" first="Chul" last="Kim">Chul Kim</name></noRegion><name sortKey="Baek, Seung Bin" sort="Baek, Seung Bin" uniqKey="Baek S" first="Seung Bin" last="Baek">Seung Bin Baek</name><name sortKey="Kim, Do Hun" sort="Kim, Do Hun" uniqKey="Kim D" first="Do Hun" last="Kim">Do Hun Kim</name><name sortKey="Lee, Hee Cheon" sort="Lee, Hee Cheon" uniqKey="Lee H" first="Hee Cheon" last="Lee">Hee Cheon Lee</name><name sortKey="Lee, Hyeong Ju" sort="Lee, Hyeong Ju" uniqKey="Lee H" first="Hyeong Ju" last="Lee">Hyeong Ju Lee</name><name sortKey="Lim, Sung Chul" sort="Lim, Sung Chul" uniqKey="Lim S" first="Sung Chul" last="Lim">Sung Chul Lim</name></country><country name="États-Unis"><noRegion><name sortKey="Kim, Chul" sort="Kim, Chul" uniqKey="Kim C" first="Chul" last="Kim">Chul Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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